期刊
GENE
卷 390, 期 1-2, 页码 199-205出版社
ELSEVIER
DOI: 10.1016/j.gene.2006.08.032
关键词
LINE-1; retrotransposon; APOBEC; transposable element
资金
- NIAID NIH HHS [R01 AI065301, AI65301] Funding Source: Medline
- NIGMS NIH HHS [5T32GM07544, R01 GM060518, R01 GM060518-07, GM60518, T32 GM007544] Funding Source: Medline
The non-LTR retrotransposon LINE-1 (L1) comprises similar to 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition processes. We demonstrate that APOBEC3G selectively inhibits Alu retrotransposition in an OR-F I p-in dependent manner. An active cytidine deaminase site is not required for the inhibition of Alu retrotransposition and the resultant integration events lack G to A or C to T hypermutation. These data demonstrate a differential restriction of L1 and Alu retrotransposition by APOBEC3G, and suggest that the Alu ribonucleoprotein complex may be targeted by APOBEC3G. (c) 2006 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据