Isotopic enrichment enhancement in metabonomic analysis of UPLC-MS data sets

Isotopic enrichment of compounds dosed in drug metabolism studies greatly enhances the spectroscopic differentiation of xenobiotic and endogenous metabolites. We show the application of (CN)-C-13-N-15 labelling of a model drug (4-cyanoaniline) as an aid to metabonomic studies of UPLC-MS-generated metabolic data sets. Copyright (c) 2007 John Wiley & Sons, Ltd.