期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 13, 页码 3824-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja070187v
关键词
-
A new concept in catalytic asymmetric olefin metathesis is introduced: a nonreacting enoate or ynoate group can be used to alter and significantly enhance the enantioselectivity. Catalytic asymmetric ring-opening/cross-metathesis (AROM/CM) processes proceed in <= 30% ee with non-styrenyl cross partners. However, with olefin partners bearing an enoate or ynoate group (1,6-diene or 1,6-enyne), catalytic AROM/CM affords the desired products in up to 98% ee, with the opposite sense of enantioselectivity versus reactions with styrene or aliphatic cross partners. This new method, for the first time, extends the scope of effective metal-catalyzed AROM/CM to reactions of non-styrenyl alkenes and cyclopropenes, a diverse and readily available set of substrates, and that of Ru-catalyzed asymmetric olefin metathesis to include processes that bear all-carbon quaternary stereogenic centers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据