期刊
CELL
卷 129, 期 1, 页码 207-219出版社
CELL PRESS
DOI: 10.1016/j.cell.2007.02.038
关键词
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资金
- NIGMS NIH HHS [GM66778] Funding Source: Medline
- NINDS NIH HHS [T32 NS007292, NS44232] Funding Source: Medline
Previous work in Drosophila has defined two populations of circadian brain neurons, morning cells (M-cells) and evening cells (E-cells), both of which keep circadian time and regulate morning and evening activity, respectively. It has long been speculated that a multiple oscillator circadian network in animals underlies the behavioral and physiological pattern variability caused by seasonal fluctuations of photoperiod. We have manipulated separately the circadian photoentrainment pathway within E- and M-cells and show that E-cells process light information and function as master clocks in the presence of light. M-cells in contrast need darkness to cycle autonomously and dominate the network. The results indicate that the network switches control between these two centers as a function of photoperiod. Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season.
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