期刊
SCIENCE
卷 316, 期 5821, 页码 109-112出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1139080
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资金
- NHLBI NIH HHS [HL055672] Funding Source: Medline
- NIDDK NIH HHS [DK070272] Funding Source: Medline
- NIGMS NIH HHS [R01 GM051377, R01 GM051377-15] Funding Source: Medline
In budding yeast, phosphate starvation triggers inhibition of the Pho80-Pho85 cyclin-cyclin-dependent kinase (CDK) complex by the CDK inhibitor Pho81, leading to expression of genes involved in nutrient homeostasis. We isolated myo-D-inositol heptakisphosphate (IP7) as a cellular component that stimulates Pho81-dependent inhibition of Pho80-Pho85. IP7 is necessary for Pho81- dependent inhibition of Pho80-Pho85 in vitro. Moreover, intracellular concentrations of IP7 increased upon phosphate starvation, and yeast mutants defective in IP7 production failed to inhibit Pho80-Pho85 in response to phosphate starvation. These observations reveal regulation of a cyclin-CDK complex by a metabolite and suggest that a complex metabolic network mediates signaling of phosphate availability.
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