期刊
BRAIN RESEARCH
卷 1140, 期 -, 页码 188-194出版社
ELSEVIER
DOI: 10.1016/j.brainres.2006.03.006
关键词
iron chelation; ferritin; aging; dopamine; neurodegeneration; Parkinson's disease
资金
- NINDS NIH HHS [NS41264] Funding Source: Medline
Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dop amine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases. (c) 2006 Elsevier B.V. All rights reserved.
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