期刊
TETRAHEDRON LETTERS
卷 48, 期 15, 页码 2679-2682出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.02.075
关键词
peptoids; N-alkyl glycines; oligomers; bioinspired polymers
资金
- NCI NIH HHS [R01 CA104569, R01 CA104569-04] Funding Source: Medline
Peptoids (N-substituted polyglycines) represent a class of bioinspired oligomers that have unique physical and structural properties. Here, we report the construction of 'extended peptoids' based on aromatic building blocks, in which the N-alkylaminoacetyl group of the peptoid backbone has been replaced by an N-alkylaminomethylbenzoyl spacer. Both meta- and para-bromomethylbenzoic acids were synthesized, providing access to a new class of peptoids. Further, inclusion of hydrophilic side chains confers water solubility to these compounds, showing that, like simple peptoids, extended peptoids add an extra dimension to synthetic poly-amide oligomers with potential application in a variety of biological contexts. (c) 2007 Elsevier Ltd. All rights reserved.
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