期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 14, 页码 4164-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja070812w
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The structure elucidation and enantioselective total synthesis of the potent HMG-CoA reductase inhibitor FR901512 were accomplished. FR901512 was prepared in 15 steps from the commercially available 2-bromo-4-methylbenzaldehyde via FR901516 in 16.3% overall yield (89% average yield). The catalytic asymmetric Nozaki-Hiyama reactions developed by us proved their applicability and reliability through this work, enabling the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.
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