期刊
CANCER
卷 109, 期 8, 页码 1454-1461出版社
WILEY
DOI: 10.1002/cncr.22552
关键词
mesothelioma; VEGF; EGFR; p16(INK4A); p14(ARF); Wnt; bcl-2 genes
类别
资金
- NCI NIH HHS [R01 CA 093708-01A3, R01 CA093708-03, R01 CA093708] Funding Source: Medline
Malignant mesothelioma (MM) is a highly aggressive tumor with a very poor prognosis. The disease is largely unresponsive to conventional chemotherapy or radiotherapy, and most patients die within 10-17 months of the first symptoms. Novel, more effective therapeutic strategies are needed for this inexorably fatal disease. Improvement in our understanding of the molecular biology of MM has identified promising new candidates for targeted treatments. In this review the key molecular signaling pathways, including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), Wnt, and the cell cycle control genes p53, pRb, and bcl-2 that appear to play an important role in the pathogenesis of MM are explored.
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