4.7 Article

Formation and stability of a suspended biomimetic lipid bilayer on silicon submicrometer-sized pores

期刊

JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 308, 期 2, 页码 337-343

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2006.11.050

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lipid bilayer; pore-spanning bilayer; membrane-mimetic; Langmuir-Blodgett film; atomic force microscopy (AFM)

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We report the fabrication of a thin silicon membrane with an array of micrometer and submicrometer pores that acts as a scaffold for suspending a lipid bilayer. We successfully deposited a lipid bilayer by the Langmuir-Blodgett method on a synthetic silicon membrane bearing arrays of pores with sizes of 1000, 650, and 300 nm. Topographic images obtained by AFM showed a suspended lipid film spanning the pores, whatever the pore size. Higher stability of bilayers supported on smaller pores was shown by AFM characterization. These results represent an important first step to creating a biomimetic environment to study cell membrane dynamics and/or in developing a biosensor. (c) 2006 Elsevier Inc. All rights reserved.

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