期刊
GENE
卷 391, 期 1-2, 页码 161-170出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2006.12.016
关键词
endothelial cell; vascular endothelial growth factor; tumor stroma; breast cancer
资金
- NCI NIH HHS [CA102583, P01 CA102583] Funding Source: Medline
SHEP1, BCAR3 and NSP1 are the three members of a family of cytoplasmic proteins involved in cell adhesion/migration and antiestrogen resistance. All three proteins contain an SH2 domain and an exchange factor-like domain that binds both Ras GTPases and the scaffolding protein Cas. SHEP1, BCAR3 and NSP1 mRNAs are widely expressed in tissues, and SHEP1 and BCAR3 have multiple splice variants that differ in their 5' untranslated regions and in some cases the beginning of their coding regions. Interestingly, our data suggest that SHEP1 is highly expressed in blood vessels in mouse breast cancer models. In contrast, BCAR3 and NSP1 are more highly expressed than SHEP1 in breast cancer cells. These expression patterns suggest differential roles for the three genes during breast cancer progression in either the vasculature or the tumor cells. (c) 2006 Elsevier B.V. All rights reserved.
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