期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 50, 期 8, 页码 1731-1734出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm070141c
关键词
-
资金
- NCI NIH HHS [R03 CA105294, R01-CA78814, R03 CA105294-01, R01 CA078814, R03 CA105294-02, R03-CA105294] Funding Source: Medline
Novel C-8a functionalized tricyclic compounds having cyano enones in rings A and C have been synthesized and biologically evaluated. Among them, compounds with acetylene groups at C-8a show extremely high potency in in vitro and in vivo bioassays for anti-inflammatory and cytoprotective activities. Both in vitro and in vivo potencies are markedly higher than those of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), which is being evaluated as an anticancer drug in phase I clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据