期刊
SCIENCE
卷 316, 期 5823, 页码 417-421出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1141314
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R37 GM038499-21, R37 GM038499] Funding Source: Medline
The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a full-genome RNA interference screen of Drosophila S2 cells, we identified about 200 genes that contribute to spindle assembly, more than half of which were unexpected. The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled.
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