期刊
SCIENCE
卷 316, 期 5824, 页码 604-608出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1141229
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资金
- NIAID NIH HHS [AI064345] Funding Source: Medline
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
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