期刊
ANESTHESIOLOGY
卷 113, 期 2, 页码 482-495出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ALN.0b013e3181e08e97
关键词
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资金
- Vifor Pharma AG, Glattbrugg, Switzerland
- University of Zurich
- Research Award Center for Zurich Integrative Human Physiology, Zurich, Switzerland
- Swiss National Science Foundation, Berne, Switzerland [SPUM 33CM30_124117]
- Swiss Foundation for Anesthesia Research, Zurich, Switzerland
- European Society of Anaesthesiology, Brussels, Belgium
- Swiss Society of Anesthesiology and Reanimation, Berne, Switzerland
- Gebert Ruef Foundation
- Swiss Life Foundation, Zurich, Switzerland
- Bundesprogramm Chancengleichheit, Berne, Switzerland
- Olga Mayenfisch Foundation
- Abbott AG, Baar, Switzerland
- B. Braun, Sempach, Switzerland
- CSL Behring, Berne, Switzerland
- Vifor SA, Villars-surGlane, Switzerland
- UBS, Zurich, Switzerland
- Stiftung fur Staublungenforschung, Zurich, Switzerland
- Novo Nordisk A/S, Bagsvard, Denmark
A systematic search was conducted to determine the characteristics of perioperative anemia, its association with clinical outcomes, and the effects of patient blood management interventions on these outcomes in patients undergoing major orthopedic surgery. In patients undergoing total hip or knee arthroplasty and hip fracture surgery, preoperative anemia was highly prevalent, ranging from 24 +/- 9% to 44 +/- 9%, respectively. Postoperative anemia was even more prevalent (51% and 87 +/- 10%, respectively). Perioperative anemia was associated with a blood transfusion rate of 45 +/- 25% and 44 +/- 15%, postoperative infections, poorer physical functioning and recovery, and increased length of hospital stay and mortality. Treatment of preoperative anemia with iron, with or without erythropoietin, and perioperative cell salvage decreased the need for blood transfusion and may contribute to improved patient outcomes. High-impact prospective studies are necessary to confirm these findings and establish firm clinical guidelines.
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