期刊
TETRAHEDRON
卷 63, 期 18, 页码 3672-3681出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.02.086
关键词
diarylmethylpiperazines; 1,2-diarylethylpiperazines; three-component reaction; arylzinc reagents; benzylzinc reagents
Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or beta-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes. (C) 2007 Elsevier Ltd. All rights reserved.
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