期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 7, 期 5, 页码 451-460出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955707780619617
关键词
chirality; enantiomers; stereoselectivity; racemic switching; drug combination; pharmacokinetics
To develop the newer pharmaceuticals and to spur the strong growth, being a general property of `handedness' chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.
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