期刊
MOLECULAR PHARMACEUTICS
卷 4, 期 3, 页码 339-346出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp070004b
关键词
pharmaceutical co-crystals; co-crystal screening; hydrogen bond; caffeine; naphthoic acid; supramolecular synthon; crystal engineering; 1-hydroxy-2-naphthoic acid; 3-hydroxy-2-naphthoic acid; 6-hydroxy-2-naphthoic acid
A group of caffeine-containing co-crystals of hydroxy-2-naphthoic acids were synthesized and analyzed via single-crystal X-ray diffraction and IR analysis. The imidazole-carboxylic acid synthon was observed in co-crystals involving 1-hydroxy-2-naphthoic and 3-hydroxy-2-naphthoic acid. In the case of 6-hydroxy-2-naphthoic acid, the co-crystal exhibits a hydrogen-bonded carboxylic acid dimer in the presence of a hydroxyl-caffeine heterosynthon.
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