期刊
NANO LETTERS
卷 7, 期 5, 页码 1318-1322出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl070345g
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资金
- NCI NIH HHS [R01 CA120480, R01 CA120480-01, 1R01 CA120480] Funding Source: Medline
- NIH HHS [DP1 OD000798, DP1 OD000798-01, 5DP1 OD000798] Funding Source: Medline
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0940321] Funding Source: National Science Foundation
Gold nanocages with a relatively small size (e.g., similar to 45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 x 10(-14) m(2), facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with an intensity threshold of 1.5 W/cm(2) to induce thermal destruction to the cancer cells. In the intensity range of 1.5-4.7 W/cm(2), the circular area of damaged cells increased linearly with the irradiation power density. These results suggest that this new class of bioconjugated gold nanostructures, immuno gold nanocages, can potentially serve as an effective photothermal therapeutic agent for cancer treatment.
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