期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 9, 期 3, 页码 473-476出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc060159t
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资金
- NIGMS NIH HHS [P50 GM069663-01, P50 GM069663-010002, P50 GM069663-020002, P50 GM069663-030002, P50 GM069663, P50 GM-069663, P50 GM069663-02, P50 GM069663-03] Funding Source: Medline
The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polymer-bound phosphine to scavenge excess hydroxyalkyl azide. Thus, a 60-member library of various disubstituted oxazolines and di- and trisubstituted dihydrooxazines was generated.
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