期刊
GENETICS
卷 176, 期 1, 页码 343-349出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.106.067314
关键词
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F-1 hybrid male sterility is thought to result from interactions between loci on the X chromosome and dominant-acting loci on the autosomes. While X-linked loci that contribute to hybrid male sterility have been precisely localized in many animal taxa, their dominant autosomal interactors have been more difficult to localize precisely and/or have been shown to be of relatively smaller effect. Here, we identified and mapped at least four dominant autosomal factors contributing to hybrid male sterility in the allopatric species pair Drosophila. permilis and A pseudoobscura bogotana. Using these results, we tested predictions of reduced recombination models of speciation. Consistent With these models, three of the four QTL associated with hybrid male sterility occur in collinear (uninverted) regions of these genomes. Furthermore, these QTL do not contribute significantly to hybrid male sterility in crosses between the sympatric species D. persitnilis and A pseudoobscurapseudoobscura. The autosomal loci identified in this study provide the basis for introgression mapping and, ultimately, for molecular cloning of interacting genes that contribute to F-1 hybrid sterility.
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