期刊
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
卷 18, 期 7, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/ijnp/pyu119
关键词
addiction; delay discounting; dopamine; impulsivity; positron emission tomography
资金
- NIH [R01 DA020726, P20 DA022539, M0I RR00865]
- [T32 DA024635]
Background: Individuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions. Indirect evidence suggests that low dopamine D-2-type receptor availability in the striatum contributes to the propensity of these individuals to sacrifice long-term goals for short-term gain; however, this possibility has not been tested directly. We investigated whether striatal D-2/D-3 receptor availability is negatively correlated with the preference for smaller, more immediate rewards over larger, delayed alternatives among research participants who met DSM-IV criteria for methamphetamine (MA) dependence. Methods: Fifty-four adults (n = 27 each: MA-dependent, non-user controls) completed the Kirby Monetary Choice Questionnaire, and underwent positron emission tomography scanning with [F-18] fallypride. Results: MA users displayed steeper temporal discounting (p = 0.030) and lower striatal D-2/D-3 receptor availability (p < 0.0005) than controls. Discount rate was negatively correlated with striatal D-2/D-3 receptor availability, with the relationship reaching statistical significance in the combined sample (r = -0.291, p = 0.016) and among MA users alone (r = -0.342, p = 0.041), but not among controls alone (r = -0.179, p = 0.185); the slopes did not differ significantly between MA users and controls (p = 0.5). Conclusions: These results provide the first direct evidence of a link between deficient D-2/D-3 receptor availability and steep temporal discounting. This finding fits with reports that low striatal D-2/D-3 receptor availability is associated with a higher risk of relapse among stimulant users, and may help to explain why some individuals choose to continue using drugs despite knowledge of their eventual negative consequences. Future research directions and therapeutic implications are discussed.
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