期刊
ONCOGENE
卷 26, 期 24, 页码 3582-3586出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210132
关键词
c-Myc; E-cadherin; transformation; epithelial cell; EMT
资金
- MRC [G0700240] Funding Source: UKRI
- Medical Research Council [G0700240] Funding Source: researchfish
- Medical Research Council [G0700240] Funding Source: Medline
- NCI NIH HHS [CA80320] Funding Source: Medline
c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.
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