期刊
NATURE CELL BIOLOGY
卷 9, 期 5, 页码 556-U136出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1569
关键词
-
类别
资金
- NCI NIH HHS [CA78048] Funding Source: Medline
- NIA NIH HHS [R01 AG011085] Funding Source: Medline
Defects in chromosome-microtubule attachment trigger spindle-checkpoint activation and delay mitotic progression(1,2). How microtubule attachment is sensed and integrated into the steps of checkpoint-signal amplification is poorly understood. In a functional genomic screen targeting human kinases and phosphatases, we identified a microtubule affinity-regulating kinase kinase, TAO1 (also known as MARKK) as an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 interacts with the checkpoint kinase BubR1 and promotes enrichment of the checkpoint protein Mad2 at sites of defective attachment, providing evidence for a regulatory step that precedes the proposed Mad2-Mad1 dependent checkpoint- signal amplification step(3). We propose that the dual functions of TAO1 in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in human cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据