期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1773, 期 5, 页码 653-660出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.06.013
关键词
epithelial cell; morphogenesis; ERM protein; membrane-cytoskeleton interaction
ERM (Ezrin, Radixin, Moesin) proteins are membrane-cytoskeleton linkers that regulate the structure and the function of specific domains of the plasma membrane. ERM proteins are expressed in all metazoan analyzed so far. Genetic analysis of ERM protein functions has recently been performed simultaneously in three different organisms, mouse, Drosophila melanogaster and C. elegans. These studies have revealed a remarkable conservation of the protein functions through evolution. Moreover they have shed light on the crucial role these proteins play in various physiological processes that occur in epithelial cells. (c) 2006 Elsevier B.V All rights reserved.
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