期刊
BIOPHYSICAL JOURNAL
卷 92, 期 9, 页码 L73-L75出版社
BIOPHYSICAL SOCIETY
DOI: 10.1529/biophysj.107.104257
关键词
-
类别
资金
- NCRR NIH HHS [RR08630, P41 RR008630] Funding Source: Medline
- NHLBI NIH HHS [HL075494, HL62426, P01 HL062426, R01 HL075494] Funding Source: Medline
It is generally assumed that the myofilament lattice in intact (i.e., nonskinned) striated muscle obeys constant volume. However, whether such is the case during the myocardial contraction is unknown. Accordingly, we measured inter. lament spacing by x-ray diffraction in ultra-thin isolated rat right ventricular trabeculae during a short 10 ms shuttered exposure either just before electrical stimulation (diastole), or at the peak of the contraction (systole); sarcomere length (SL) was held constant throughout the contraction using an iterative feedback control system. SL was thus varied in a series of SL-clamped contractions; the relationship between SL and inter. lament spacing was not different between diastole and systole within 1%; this was true also over a wide range of inotropic states induced by varied [Ca2+](o). We conclude that the cardiac myofilament lattice maintains constant volume, and thus constant interfilament spacing, during contraction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据