期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 7, 期 3, 页码 231-236出版社
FUTURE DRUGS LTD
DOI: 10.1586/14737159.7.3.231
关键词
cost-effectiveness; fluorescence in situ hybridization; peptide nucleic acid; real-time assay
类别
Inappropriate and inaccurate antimicrobial therapy can lead to adverse patient outcomes and also the development of antimicrobial resistance. Peptide nucleic acid (PNA) fluorescence in situ hybridization (FISH) gives rapid reporting with highly sensitive and specific results to clinicians within 3 h after blood cultures turn positive, thereby offering targeted therapeutics where necessary. It is simple to establish compared with real-time PCR and has resulted in significant cost savings for hospitals. PNA FISH is a promising future technology for the microbiology laboratory that will impact on patient management and clinical guidelines. This article will review the clinical data supporting these new technologies.
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