期刊
JOURNAL OF NEUROCHEMISTRY
卷 101, 期 4, 页码 1099-1107出版社
WILEY
DOI: 10.1111/j.1471-4159.2007.04482.x
关键词
allatostatin; crustaceans; ESI-Q-TOF MS; neuromodulation; neuropeptides; pericardial organs
资金
- NIDDK NIH HHS [R01 DK071801, DK071801] Funding Source: Medline
- NINDS NIH HHS [R01 NS017813, NS17813] Funding Source: Medline
The neural networks in the crustacean stomatogastric ganglion are modulated by neuroactive substances released locally into the neuropil of the stomatogastric ganglion and by circulating hormones released by neuroendocrine structures including the pericardial organs. Using nanoscale liquid chromatography coupled to electrospray ionization quadrupole-time-of-flight mass spectrometry, we have identified and sequenced a novel B type allatostatin (CbAST-B1), VPNDWAHFRGSWamide, present in the pericardial organs of the crabs, Cancer borealis, and Cancer productus. We describe the physiological actions of CbAST-B1 on the pyloric rhythm of the stomatogastric ganglion of the crab, Cancer borealis. CbAST-B1 reduces the pyloric network frequency in a dose-dependent manner. The effect of bath-applied CbAST-B1 depends on the preceding physiological state of the preparation. Surprisingly, despite marked amino-acid sequence dissimilarity between the novel CbAST-B1 and the A type allatostatin family of peptides (AST-A), the physiological effects of CbAST-B1 are similar to those of AST-A.
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