期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 9, 页码 2558-2560出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.02.008
关键词
chromenes; natural products; fungal metabolites; antiinflammatory agents; oxidative burst
The fungus Daedalea quercina (oak mazegill) was examined for its capability of producing antioxidative and anti-inflammatory compounds. Bioactivity guided fractionation of the extract from a mycelial culture led to the isolation of quercinol, which was identified as (-)-(2S)-2-hydroxymethyl-2-inethyl-6-hydroxychromene 1 by NMR and X-ray analyses. The cryptic hydroquinone I shows a broad anti-inflammatory activity against cyclooxygenase 2 (COX-2), xanthine oxidase (XO), and horseradish peroxidase (HRP) at micromolar concentrations. (c) 2007 Elsevier Ltd. All rights reserved.
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