期刊
EXPERIMENTAL GERONTOLOGY
卷 42, 期 5, 页码 412-415出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.11.015
关键词
aging; NK cell receptor; co-stimulatory receptor
资金
- Intramural NIH HHS [Z01 AG000757-10, Z01 AG000756-10] Funding Source: Medline
- NIDA NIH HHS [R90 DA023426] Funding Source: Medline
Accumulation of CD28(-)CDS T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets from naive to memory (CD28(+) to CD28(-)) cells and the growth of CD28+ and CD28(-)CD8 memory T cells in response to homeostatic cytokine interleukin 15 (IL-15). At the gene expression level, one of the most striking changes is the altered expression of some co-stimulatory receptors and various NK cell receptors in CD28(-)CD8 T cells. Furthermore, CD28(-)CD8 T cells appear to have a normal proliferation response to IL-15 in vitro. Interestingly, IL-15 is also capable of inducing stable loss of CD28 expression in actively dividing CD28(+)CD8 memory T cells. Together, these findings provide the gene expression features of CD28(-)CD8 T cells that differ from their CD28(+) counterparts and suggest a possible role of IL-15 in the increase of CD28-CD8 T cells that occurs with aging. (C) 2006 Elsevier Inc. All rights reserved.
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