期刊
NATURE CHEMICAL BIOLOGY
卷 3, 期 5, 页码 252-262出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio876
关键词
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资金
- NIGMS NIH HHS [T32 GM008275, R01 GM054616] Funding Source: Medline
Foldamers are sequence- specific oligomers akin to peptides, proteins and oligonucleotides that fold into well- defined three- dimensional structures. They offer the chemical biologist a broad pallet of building blocks for the construction of molecules that test and extend our understanding of protein folding and function. Foldamers also provide templates for presenting complex arrays of functional groups in virtually unlimited geometrical patterns, thereby presenting attractive opportunities for the design of molecules that bind in a sequence- and structure- specific manner to oligosaccharides, nucleic acids, membranes and proteins. We summarize recent advances and highlight the future applications and challenges of this rapidly expanding field.
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