期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 22, 期 3, 页码 265-280出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911507078268
关键词
polymer; scaffold; electrohydrodynamic; printing; tissue engineering
In this paper, we uncover a new method for the preparation of biopolymer scaffolds and demonstrate its potential for the development of organs with the aid of tissue engineering. Two novel nanocomposite polymers, a nonbiodegradable polyhedral oligomeric silsesquioxane-poly (carbonate-urea)urethane and a biodegradable polyhedral oligomeric silsesquioxane-polycaprolactone-poly(carbonate-urea)urethane, have been subjected to flow in an electric field. Electrically forced microthreading of the polymers occurs and a three-dimensional print-patterning device was used to deposit fine (< 50 mu m) threads of polymer according to a predesigned architecture to prepare scaffolds. The technique can offer tremendous potential in the development of organs.
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