期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 137, 期 3, 页码 244-247出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2007.06565.x
关键词
MPL mutation; myelofibrosis; JAK2(V617F); anaemia; myeloproliferative disorders
类别
The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8.2%) had an MPL mutation, four of which (22%) co-existed with JAK2(V617F) mutation. When compared with MPL wild-type patients, irrespective of JAK2(V617F) status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0.02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0.002) and were more likely to require regular transfusional support (P = 0.012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
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