期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 32, 期 5, 页码 235-245出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2007.03.009
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资金
- NIAID NIH HHS [AI 40127] Funding Source: Medline
- NIGMS NIH HHS [GM 075256] Funding Source: Medline
The use of Ca2+ for intracellular signalling necessitates tight local and global control of cytoplasmic Ca2+ concentration, and mechanisms for maintaining the net Ca2+ balance. It has long been recognized that intracellular Ca2+ stores exert control over Ca2+ influx at the plasma membrane through a process of store-operated Ca2+ entry (SOCE). The Ca2+ current I-CRAC is the best characterized instance of SOCE, but the elements of the pathway leading to I-CRAC have eluded biochemical definition for more than a decade. However, the recent identification of key proteins underlying I-CRAC-STIM1 and Orai1 - has led to several insights into this ER-to-plasma membrane signalling system and to the recognition that it is an ancient and conserved mechanism in multicellular organisms.
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