期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 618, 期 1-2, 页码 41-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2006.07.010
关键词
SWI/SNF; ISWI; HMG; acetylation; phosphorylation; phosphoinositides; inositolpolyphosphates
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000H125] Funding Source: Medline
- Medical Research Council [G0701175] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000H125] Funding Source: researchfish
The plasticity of chromatin is governed by multi-subunit protein complexes that enzymatically regulate chromosomal structure and activity. Such complexes include ATP-dependent chromatin remodelling factors that are involved in many fundamental processes such as transcription, DNA repair, replication and chromosome structure maintenance. Because ATP-dependent chromatin remodelling factors play important roles, it is not surprising to find that their functions are regulated in a plethora of ways, including post-translational modifications of their subunits and subunit composition changes. The activity of these enzymes is modulated by many factors, including linker histones, histone variants, histone chaperones, non-histone chromatin constituents such as HMG-proteins and secondary messengers, such as inositolpolyphosphates. Additionally, specific histone modifications and interaction with site-specific transcriptional regulators direct the targeting of these activities. Understanding the network of mechanisms that control ATP-dependent chromatin remodelling will constitute an important challenge towards our understanding of chromatin dynamics. (C) 2007 Elsevier B.V. All rights reserved.
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