期刊
MOLECULAR DIVERSITY
卷 11, 期 2, 页码 73-80出版社
SPRINGER
DOI: 10.1007/s11030-007-9059-3
关键词
aminotriazole; imidazole[1,2-b]-1,2,4-triazole; multicomponent reactions (MCRs); cytotoxic activity
A simple and effective method for the synthesis of bioactive imidazo[1,2,4]triazole analogues has been developed utilizing the MCR technique, which involved the reaction of aminotriazoles, isocyanides and aldehydes. The products were characterized by H-1, (NMR)-N-13 spectroscopy, MS and elemental analysis. Interestingly, compounds 19d, 21a, 21b and 21h displayed good cytotoxic activities at 10(-4) M concentration in the inhibition of tumor cell growth as evaluated by the MTT method.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据