期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 9, 期 3, 页码 407-414出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc060161k
关键词
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Herein, we report the automated parallel synthesis of solution-phase libraries of phosphoramidite ligands for the development of enantioselective catalysts. The ligand libraries are screened in situ in the asymmetric rhodium-catalyzed addition of arylboronic acids to aldehydes and imines. It is shown that the described methodology results in the straightforward discovery of leads for highly efficient enantioselective catalysts.
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