期刊
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
卷 2, 期 3, 页码 328-334出版社
WILEY
DOI: 10.1002/tee.20147
关键词
silicon microneedle; isotropic dry etching; three-dimensional sharp tip; three-dimensional shank shape; penetration experiment
This paper proposes a novel fabrication method for long solid microneedles made of silicon, which have a three-dimensional sharp tip, by using isotropic dry etching. Since the fabrication is done in a direction parallel to the surface of the silicon substrate, there is no limit for the needle length. Also, the shank shape of this needle is freely designed three-dimensionally by defining the mask on the silicon surface. For example, a jagged or harpoon shape is possible by using the proposed method, which may be effective for some medical applications. First, several three-dimensional, complicated-shaped needles with sharp tip angles were fabricated by changing the mask pattern. Second, a penetration experiment with them on an artificial skin was carried out, and easy penetration comparable with a conventional metal solid needle was confirmed. For an example of lancet application for diabetics, one of the needles was inserted into a human skin, and bleeding was confirmed. (c) 2007 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
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