期刊
CELL CYCLE
卷 6, 期 9, 页码 1011-1018出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.9.4219
关键词
sirtuins; SIRT1-7; NAD(+); deacetylase; mitotic regulation; mitotic checkpoint; hyperploidy; chromosomal instability; tumorigenesis; microtubule inhibitors
类别
Sir2, an NAD(+)-dependent protein deacetylase, extends the lifespan in diverse species from yeast to flies. Mammals have seven homologs of Sir2, SIRT1-7, which affect aging and metabolism and which are potential targets for pharmacologic intervention. We identified SIRT2, which preferentially deacetylates tubulin and histone H4, as a downregulated protein in gliomas due to its epigenetic aberration. We herein discuss the role of SIRT2 in the mitotic checkpoint function and show that it may be as a potential target of anti-cancer drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据