期刊
PLOS GENETICS
卷 3, 期 5, 页码 655-660出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.0030084
关键词
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资金
- NIA NIH HHS [P30AG013280, P30 AG013280, R01 AG024287] Funding Source: Medline
In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in invertebrate eukaryotic model organisms. Of these, single-celled yeast is the least complicated and most amenable to genetic and molecular manipulations. Supporting the use of this organism for aging research, increasing evidence has accumulated that a subset of pathways influencing longevity in yeast are conserved in other eukaryotes, including mammals. Here we briefly outline aging in yeast and describe recent. ndings that continue to keep this simple'' eukaryote at the forefront of aging research.
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