期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 87, 期 1, 页码 65-72出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2007.04.001
关键词
alcohol; alcoholism; novel anticonvulsants; sulfamates; sulfonamides; topiramate; zonisamide
资金
- NIAAA NIH HHS [R01 AA013727, R01 AA013727-04, R21AA13425, R21 AA013425, R21 AA013425-03] Funding Source: Medline
- NIDA NIH HHS [K05 DA000099, K05 DA000099-17, K05-DA00099] Funding Source: Medline
Several anticonvulsant agents, including topiramate and valproate, have been found to reduce alcohol consumption in rodent models of drinking. The question of whether the novel anticonvulsant agent, zonisamide, shares similar actions in either mice or rats was investigated in the present experiments. In an initial experiment, the consumption of a 10% ethanol-5% sucrose solution, available for one hour, by Wistar rats treated with lactose, topiramate, or zonisamide was determined. In a second experiment, the intake of a 10% ethanol/water solution, accessible for two hours, by C57BL/B6N mice treated with either zonisamide or vehicle was assessed. In the rat, 50 mg/kg (PO) doses of either topiramate or zonisamide produced significant, but moderate decreases in ethanol/sucrose intake. The administration of a 50 mg/kg (IP) dose of zonisamide to mice resulted in a marked lowering in ethanol consumption. These results provide evidence that zonisamide administration will decrease ethanol consumption by both mice and rats in limited access models of drinking, and might, like topiramate, be useful as a medication for alcoholism. (c) 2007 Elsevier Inc. All rights reserved.
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