期刊
JOURNAL OF EXPERIMENTAL BIOLOGY
卷 210, 期 9, 页码 1607-1612出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jeb.004887
关键词
age regulation; gene expression profile; electron transport chain; gene set enrichment analysis; aging; evolution; genomics
类别
资金
- NIA NIH HHS [R01 AG025941] Funding Source: Medline
Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species.
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