期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 618, 期 1-2, 页码 116-129出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2006.05.040
关键词
chromatin; nucleosome; histories; exchange; transcription; elongation
资金
- NIGMS NIH HHS [R01 GM058650, GM58650] Funding Source: Medline
The process of transcript elongation by RNA polymerase II (Pol II) involves transcription-dependent exchange and displacement of all core histones and is tightly controlled by numerous protein complexes modifying chromatin structure. These processes can contribute to regulation of transcription initiation and elongation, as well as the chromatin state. Recent data suggest that the histone octamer is displaced from DNA at a high rate of transcription, but can survive less frequent transcription that is accompanied only by partial loss of H2AIH2B histones. Here we propose that critical density of Pol Il molecules could be required for displacement of the histone octamer and discuss mechanisms that are most likely involved in the processes of histone exchange. (C) 2007 Elsevier B.V. All rights reserved.
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