期刊
EXPERT OPINION ON DRUG SAFETY
卷 6, 期 3, 页码 279-288出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740338.6.3.279
关键词
adverse events; efficacy; IFN-beta; multiple sclerosis; safety
Multiple sclerosis, a chronic demyelinating disease of the CNS, is now a treatable disease. Phase III clinical trials of three recombinant IFN-beta products conducted in relapsing-remitting multiple sclerosis have shown, albeit modest, significant effects on relapses and short-term progression of disability, and a more substantial effect on MRI parameters. However, these effects do not correlate well with clinical disease activity or long-term disability. Overall, IFN-beta is safe and generally well tolerated, and reported adverse events were comparable between preparations. Systemic side effects can be effectively managed by dose escalation, use of an auto-injector and careful clinical monitoring.
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