期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 5, 页码 1339-1346出版社
WILEY
DOI: 10.1002/dvdy.21130
关键词
dopamine; D1 receptor; retina; CNS; zebrafish
资金
- NEI NIH HHS [R01 EY15402, R01 EY13147, R01 EY13680, R01 EY013147] Funding Source: Medline
Dopamine plays important roles in the regulation of central nervous system (CNS) development and functions. In vertebrates, two families of dopamine receptors, collectively known as dopamine D1 and D2 receptors, have been identified. Recently, dopamine receptors have been targeted by pharmacological and therapeutic studies of neurological disorders, such as Parkinson's disease. Here, we report a study on the molecular characterization of dopamine Dl receptor in zebrafish (Danio rerio). We cloned the full-length cDNA of a zebrafish dopamine Dl receptor, designated as drill. The sequence of drd1 shares high homology to the sequences of dopamine D1 receptors in mammalian, amphibian, and other fish species. drd1 is expressed in the CNS. The first drd1 expression was observed at approximately 30 hours postfertilization, at which time the expression was seen in the developing diencephalon and hindbrain. In developing retinas, the expression of drd1 was detected in the inner nuclear layer with the exception of the marginal zones. In adult retinas, drd1 expression was detected in most cell types in the inner and outer nuclear layers as well as ganglion cell layer. Differential expression of drd1 in developing and adult retinas may play various roles in regulating visual system functions. Developmental Dynamics 236:1339-1346, 2007. (C) 2007 Wiley-Liss, Inc.
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