Correlation between enhancement pattern of hepatocellular carcinoma on real-time contrast-enhanced ultrasound and tumour cellular differentiation on histopathology

The objective of this study was to evaluate the correlation between the enhancement pattern of hepatocellular carcinoma (HCQ on contrast-enhancedultrasound (CEUS) and tumour cellular differentiation on histopathology. 189 HCC lesions in 189 patients were retrospectively evaluated with CEUS and histopathological examination. CEILIS was performed with SonoVue and contrast pulse sequencing. Histopathological diagnoses were made according to the Edmonson grading system. Significant differences were shown between the time that the HCC became hypoenhancing or remained echogenic in late phase and tumour cellular differentiation (p=0.006; p=0.036), but not with the time of commencement of hyperenhancing or commencement of isclenhancing in arterial phase and portal phase (p=0.164, p 0.1113; p-0.186, p-0.070). The timing of HCC becoming hypoenhancing on CEUS is correlated with tumour cellular differentiation; well differentiated turnours wash out more slowly than poorly differentiated ones.