期刊
AMINO ACIDS
卷 32, 期 4, 页码 523-526出版社
SPRINGER
DOI: 10.1007/s00726-006-0427-6
关键词
S-nitrosylation; apoptosis; nitric oxide; caspases; GAPDH; NMDA; thioredoxin, Ask1, FLIP
S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.
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