4.7 Article

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

期刊

INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 10, 期 -, 页码 4957-4969

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S82980

关键词

ceria nanoparticles; radiotherapy; breast cancer cells; neogambogic acid; radiosensitization

资金

  1. National Key Basic Research Program of China (973 Program) [2013CB933904]
  2. National Nature Science Foundation of China [31400721]
  3. Nature Science Foundation of Jiangsu Province [BK20131355]
  4. Priority Academic Program Development of Jiangsu Higher Education Institutions

向作者/读者索取更多资源

Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation doses required to kill cancer cells and thereby minimizing collateral damage to healthy adjacent tissue.

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