期刊
HUMAN BRAIN MAPPING
卷 28, 期 5, 页码 383-393出版社
WILEY
DOI: 10.1002/hbm.20281
关键词
decision-making; delay discounting; functional magnetic resonance imaging; methamphetamine
资金
- Intramural NIH HHS [Z01 DA000051] Funding Source: Medline
- NCRR NIH HHS [5M01RR000865-31, P20RR020750, M01 RR000865, P20 RR020750] Funding Source: Medline
- NIDA NIH HHS [R01 DA015179, 3R01 DA015179-02S1, K01 DA0051-01A1] Funding Source: Medline
Relative to individuals who do not have addictive disorders, drug abusers exhibit greater devaluation of rewards as a function of their delay (delay discounting). The present study sought to extend this finding to methamphetamine (MA) abusers and to help understand its neural basis. MA abusers (n = 12) and control subjects who did not use illicit drugs (n = 17) participated in tests of delay discounting with hypothetical money rewards. We then used a derived estimate of each individual's delay discounting to generate a functional magnetic resonance imaging probe task consisting of three conditions: hard choices, requiring selections between smaller, sooner and larger, later alternatives that were similarly valued given the individual's delay discounting; easy choices, in which alternatives differed dramatically in value; and a no choice control condition. MA abusers exhibited more delay discounting than control subjects (P < 0.05). Across groups, the hard choice > no choice contrast revealed significant effects in the ventrolateral prefrontal cortex, dorsolateral prefrontal cortex (DLPFC), dorsal anterior cingulate cortex, and areas surrounding the intraparietal sulcus (IPS). With group comparisons limited to these clusters, the hard choice > easy choice contrast indicated significant group differences in task-related activity within the left DLPFC and right IPS; qualitatively similar nonsignificant effects were present in the other clusters tested. Whereas control subjects showed less recruitment associated with easy than with hard choices, MA abusers generally did not. Correlational analysis did not indicate a relationship between this anomaly in frontoparietal recruitment and greater degree of delay discounting exhibited by MA abusers. Therefore, while apparent inefficiency of cortical processing related to decision-making in MA abusers may contribute to the neural basis of enhanced delay discounting by this population, other factors remain to be identified.
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