期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 8, 期 5, 页码 379-393出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2163
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资金
- NIGMS NIH HHS [R37 GM024364, R01 GM060678] Funding Source: Medline
- Telethon [GGP06044] Funding Source: Medline
In eukaryotes, the spindle-assembly checkpoint ( SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores - structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
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